Juliane K. Strauss-Soukup, BS, PhD

Juliane K. Strauss-Soukup, BS, PhD

Juliane K. Strauss-Soukup, BS, PhD

Professor
Vice Provost, Research and Scholarship
College of Arts and Sciences

Academic Appointments

Department

  • Chemistry and Biochemistry

Position

  • Professor

Secondary Appointment

  • Med. Microbiology & Immunology

Teaching Activity

  • Dr. Soukup teaches a wide selection of chemistry courses, including general chemistry, biochemistry, and nucleic acid biochemistry. She also mentors ~14 undergraduate research students each semester in independent research courses.

Biography

A more complete listing of scholarship, teaching, and research interests can be found in my Curriculum Vitae.

Publications and Presentations

Books

  • , 120, 173-194

Articles

  • , 196, 2799-2808
  • , 9, 2875-82
  • , 11, 2567-2571
  • , 13, 517-523
  • , 12, 1221-1226
  • , 14, 344-349
  • , 41, 10426-10438
  • , 9, 225-230
  • , 302, 339-358
  • , 5, 986-992
  • , 72, 297-306
  • , 26, 2298-2305
  • , 37, 1060-1066
  • , 272, 31570-31575
  • , 36, 10026-10032
  • , 36, 8692-8698
  • , 93, 9515-9520
  • , 3, 671-678
  • , 266, 1829-1834

Presentations

Research and Scholarship

Research and Scholarship Interests

  • My laboratory is currently interested in studying the structure and function of a number of noncoding RNAs, specifically riboswitches, allosteric ribozymes and lncRNAs. One riboswitch project involves studying the structure and function of the bacterial glmS riboswitch that is also a ribozyme. We are interested in investigating whether non-natural riboswitch ligands can modulate gene expression and therefore may be able to act as antibiotics. Another project involves discovery of new riboswitches. One we are particularly interested in is a noncoding RNA found in mammals that is highly conserved among vertebrate genes required for spermine biosynthesis. The function of this mouse RNA element as a spermine riboswitch indicates a substantially broader distribution of riboswitches among eukaryotic organisms and represents a new drug target in a key metabolic process relevant to cellular and organism survival.
     
     

Current Research Projects

  • In our work with noncoding RNAs we are currently designing a high-throughput system for studying non-natural riboswitch ligand analogs. In addition, we are collaborating with a lab on a SARS-CoV-2 project to investigate viral RNA-protein binding.

Grant Funding Received

  • National Institutes of Health INBRE Program, "Nebraska Research Network in Functional Genomics"
  • National Institutes of Health INBRE Program, “Understanding Genetic Regulation Through Structural Studies of Riboswitch-Metabolite Complexes”
  • National Institutes of Health, renewal of “Antibiotic Properties of Artificial Agonists for a Bacterial Riboswitch”
  • National Institutes of Health INBRE Program, "Nebraska Research Network in Functional Genomics"
  • Gordon Research Conference PUI (Predominantly Undergraduate Institution) Award
  • National Institutes of Health INBRE Program, supplement to "Nebraska Research Network in Functional Genomics", equipment and pilot project funding
  • National Institutes of Health, ARRA competitive supplement to “Development of Artificial Agonists for a Bacterial Riboswitch”
  • National Institutes of Health ARRA shared instrumentation grant, purchase of shared PhosphorImager Typhoon 9140,
  • National Institutes of Health, “Development of Artificial Agonists for a Bacterial Riboswitch”
  • Internal: Dr. George F. Haddix President’s Faculty Research Fund, Creighton University, “Using bacterial RNA switches as synthetic genetic devices”
  • Internal: Dr. George F. Haddix President’s Faculty Research Fund, Creighton University, “Examination of spermine riboswitch function from different organisms for the development of antibiological agents”
  • Internal: Research Incentive Grant, Creighton University College of Arts & Sciences, “Determination of Key Structural Features of a Mammalian Riboswitch in Order to Design Novel Anti-Cancer Agents”
  • CURAS Faculty Research Fund, “Antibiotic Properties of Artificial Agonists for a Bacterial Riboswitch”

Awards and Honors

  • INBRE Scholars Program, National Institutes of Health, 2016
  • INBRE Scholars Program, National Institutes of Health, 2016
  • Summer Internship Program in Biomedical Research (SIP), National Institutes of Health, 2016
  • Ferlic Summer Research Fellowship, CURAS, 2016
  • Maiben lecture invited speaker, Nebraska Academy of Sciences, 2016
  • Invited Speaker, 2016
  • Council on Undergraduate Research Councilor, Elected by Council on Undergradiate Research, 2016
  • Invited Speaker, 2015
  • Chosen for SciMix Poster Presentation, American Chemical Society, 2015
  • Ferlic Summer Research Fellowship, CURAS, 2015
  • Summer Undergraduate Research Program, Mayo Clinic, 2015
  • INBRE Scholars Program, National Institutes of Health, 2015
  • Invited Speaker, 2015
  • Invited Speaker, 2015
  • Invited Speaker, 2015
  • Summer Research Fellowship, Creighton Honors Program, 2014
  • INBRE Scholars Program, National Institutes of Health, 2014
  • Ferlic Summer Research Fellowship, CURAS, 2014
  • Nominee for Undergraduate Research Fellows Award, 2014
  • Soukup, J.K., Soukup, G.A. “Examination of spermine riboswitch function from different organisms for the development of antibiological agents”, Filed September 20, 2013, 61/880,553, 2013
  • Gordon Research Conference PUI Travel Award, 2013
  • INBRE Scholars Program, National Institutes of Health, 2013
  • INBRE Scholars Program, National Institutes of Health, 2013
  • Best Oral Presentation, 38th West Coast Biological Sciences Undergraduate Research Conference, 2013
  • Best Undergraduate Poster, St. Albert's Day Research Symposium, 2013
  • Honorary Inductee, Creighton University Alpha SIgma Nu (Jesuit Honor Society), 2013
  • College Award for Professional Excellence in Major Advising, Creighton College of Arts & Sciences, 2013
  • Award Winner, Gordon Research Conference, 2013
  • Ferlic Summer Research Fellowship, College of Arts & Sciences, 2012
  • Ferlic Summer Research Fellowship, College of Arts & Sciences, 2012
  • INBRE Scholars Program, National Institutes of Health, 2012
  • INBRE Scholars Program, National Institutes of Health, 2012
  • Outstanding Undergraduate Research in Biological Sciences, Nebraska Academy of Sciences, 2012
  • Creighton University Research Award, 2012
  • Richard Holland Future Scientist Award, Nebraska IDeA Networks of Biomedical Research Excellence Meeting, 2011
  • INBRE Scholars Program, National Institutes of Health, 2011
  • INBRE Scholars Program, National Institutes of Health, 2011
  • INBRE Scholars Program, National Institutes of Health, 2011
  • Ferlic Summer Research Fellowship, College of Arts & Sciences, 2011
  • Contributor, Luce Foundation, 2011
  • INBRE Scholars Program, National Institutes of Health, 2010
  • INBRE Scholars Program, National Institutes of Health, 2010
  • Richard Holland Future Scientist Award, 2010
  • Ferlic Summer Research Fellowship, College of Arts & Sciences, 2010
  • Ferlic Summer Research Fellowship, College of Arts & Sciences, 2010
  • INBRE Scholars Program, National Institutes of Health, 2010
  • Chosen for SciMix Poster Presentation, American Chemical Society, 2010
  • Nominee for Creighton University Research Award, 2010
  • Creighton Representative, 2010
  • Nominee for Carnegie Foundation U.S. Professors of the Year award, 2009
  • Soukup, G.A., Soukup, J.K. “GlmS ribozyme coenzymes and methods of use thereof,” International Patent Cooperation Treaty Application PCT/US 2006/21965, 2006