Department

• Pharmacology and Neuroscience

Position

• Adjunct Professor

Articles

• Philkhana SC, Mehrotra S, Murray TF, Reddy DS. Synthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers toward neuroprotection., Organic & Biomolecular Chemistry, 14, 8457-73, 2016
• Joshi AA, Murray TF, Aldrich JV. Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin, Journal of Medicinal Chemistry, 58(22), 8783-95, 2015
• Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick WH. Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows., PLoS One, 10(7), e0133297, 2015
• Murray,TF,Z.Cao,X. Li,X.Zou,M.Greenwood,WH Gerwick. Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons., Marine Drugs, 13(2), 903-19, 2015
• Maio,WA,S.Mehrotra,BM Duggan,R.Tello-Aburto,TD Newar,WH Gerwick,TF Murray. Detailed Analysis of (-)-Palmyrolide A and Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists., Journal of Natural Products, 77(11), 2553-60, 2014
• Cao Z, Cui Y, Busse E, Mehrotra S, Rainier JD, Murray TF. Gambierol inhibition of voltage-gated potassium channels augments spontaneous Ca2+ oscillations in cerebrocortical neurons., Journal of Pharmacology and Experimental Therapeutics, 350(3), 615-23, 2014
• Aldrich JV, Senadheera SN, Ross NC, Reilley KA, Ganno ML, Eans SE, Murray TF, McLaughlin JP. Alanine Analogs of [D-Trp]CJ-15,208: Novel Opioid Activity Profiles and Prevention of Drugs-and Stress-Induced Reinstatement of Cocaine-Seeking Behavior., British Journal of Pharmacology, 171(13), 3212-22, 2014
• Cao Z,Cui Y, Busse E, Mehrotra S,Rainier JD, Murray TF, Gambierol inhibition of voltage-gated potassium channels augments spontaneous Ca2+ oscillations in cerebrocortical neurons., Journal of Pharmacology and Experimental Therapeutics, Epub Ahead of print, 114.215319, 2014
• Lesma G,Salvadori S, Airaghi F, Murray TF, Recca T, Sacchetti A, Balboni G, Silvani A. Structural and biological exploration of Phe(3)-Phe(4)-modified endomorphin-2 peptidomimetics., ACS Med Chem Lett, 4(8), 795-99, 2014
• Li H, Bowling JJ, Frionczek FR, Hong J, Jabba SV, Murray TF, Ha NC, Hamann MT, Jung JH, Asteropsin A: An unusual cystine-crosslinked peptide from porifera enhances neuronal Ca(2+) influx, Biochem Biophys Acta, 1830(3), 2591-9, 2013
• George J, Baden D, Gerwick WH, Murray TF. Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity, Proceedings of the National Academy of Sciences, 109 (48), 19840-45, 2012
• Reith M, Ali S, Hashim A, Sheikh IS, Theddu N, Gaddiraju NV, Mehrotra S, Schmitt KC, Murray TF, Sershen H, Unterwald EM, Davis FS. Novel C-1 Substituted Cocaine Analogues Unlike Cocaine or Benztropine, Journal of Pharmacology and Experimental Therapeutics, Epub Ahead of print, jpet#193771, 2012
• Nunnery, JK, Engene N, Byrum T, Cao Z, Jabba SV, Pereira AR, Matainaho T, Murray TF, Gerwick WH. Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria., Journal of Organic Chemistry, 77 (9), 4198-4208, 2012
• Malloy KL,Suyama TL,Engene N,Debonsi H,Cao Z,Matainaho T,Spadafora C,Murray TF,Gerwick WH.Credneramides A and B: neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov., Journal of Natural Products, 22148360, Epub ahead of print, 2011
• Engene N, Choi H, Esquenazi E, Byrum T, Villa FA, Cao Z, Murray TF, Dorrestein PC, Gerwick L, Gerwick WH.Phylogeny-Guided Isolation of Ethyl Tumonoate A from the Marine Cyanobacterium cf. Oscillatoria margaritifera., Journal of Natural Products, 74(8), 1737-1743, 2011
• Aldrich JV, Kulkarni SS, Senadheera SN, Ross NC, Reilley KJ, Eans SO, Ganno ML, Murray TF, McLaughlin JP.Unexpected Opioid Activity Profiles of Analogues of the Novel Peptide Kappa Opioid Receptor Ligand CJ-15,208., ChemMedChem, 10.1002, Epub ahead of print, 2011
• Ross NC, Reilley KJ, Murray TF, Aldrich JV, McLaughlin JP. Novel opioid cyclic tetrapeptides: Trp isomers of CJ-15,208 exhibit distinct opioid receptor agonism and short-acting kappa opioid receptor antagonism., British Journal of Pharmacology, Epub ahead of print, 2011
• Cao Z, Shafer TJ, Crofton KM, Gennings C, Murray TF. Additivity of Pyrethroid Actions on Sodium Influx in Cerebrocortical Neurons in Primary Culture., Environmental Health Perspectives, Epub ahead of print, 2011
• Kelamangalath L, Dravid SM, George J, Aldrich JV, Murray TF. Kappa-Opioid receptor inhibition of calcium oscillations in spinal cord neurons., Molecular Pharmacology, 79(6), 1061-71, 2011
• Cao Z, Shafer TJ, Murray TF. Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons., Journal of Pharmacology and Experimental Therapeutics, 336(1), 197-205, 2011
• Fang WJ, Bennett MA, Murray TF, Aldrich JV. Deletion of Ac-NMePhe(1) from [NMePhe(1) ]arodyn under acidic conditions, part 2: effects of substitutions on pharmacological activity., Biopolymers, 96(1), 103-10, 2011
• Cao Z, Gerwick WH, Murray TF. Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNa(v)1.2, rNa(v)1.4 and rNa(v)1.5 alpha subunits., BMC Neuroscience, 11, 154, 2010
• Pereira AR, Cao Z, Engene N, Soria-Mercado IE, Murray TF, Gerwick WH. Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria., Organic Letters, 12(20):, 4490-3, 2010
• Choi H, Pereira AR, Cao Z, Shuman CF, Engene N, Byrum T, Matainaho T, Murray TF, Mangoni A, Gerwick WH. The hoiamides, structurally intriguing neurotoxic lipopeptides from Papua New Guinea marine cyanobacteria., Journal of Natural Products, 73(8), 1411-21, 2010
• Fang WJ, Bennett MA, Murray TF, Aldrich JV.Deletion of Ac-NMePhe(1) from [NMePhe(1)]arodyn under Acidic Conditions: 2. effects of substitutions on pharmacological activity.PMID: 20560148 [PubMed - as supplied by publisher], Biopolymers, 2010
• Suyama TL, Cao Z, Murray TF, Gerwick WH. Ichthyotoxic brominated diphenyl ethers from a mixed assemblage of a red alga and cyanobacterium: structure clarification and biological properties. PMID: 19638282 [PubMed - indexed for MEDLINE], Toxicon, 55(2-3), 204-10, 2010
• Cao Z, LePage KT, Frederick MO, Nicolaou KC, Murray TF.Involvement of caspase activation in azaspiracid-induced neurotoxicity in neocortical neurons.PMID: 20047973 [PubMed - indexed for MEDLINE], Toxicological sciences, 114(2), 323-34, 2010
• Jabba SV, Prakash A, Dravid SM, Gerwick WH, Murray TF.Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels.PMID: 20026674 [PubMed - indexed for MEDLINE], JPET, 332(3), 698-709, 2009
• Sinha B, Cao Z, Murray TF, Aldrich JV. Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors.PMID: 19621878 [PubMed - indexed for MEDLINE], Journal of Medicinal Chemistry, 52(23), 7372-5, 2009
• Patkar KA, Murray TF, Aldrich JV. The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues.PMID: 19807094 [PubMed - indexed for MEDLINE], Journal of Medicinal Chemistry, 52(21), 6814-21, 2009
• Soria-Mercado IE, Pereira A, Cao Z, Murray TF, Gerwick WH.Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii.PMID: 19754100 [PubMed - indexed for MEDLINE], Organic Letters, 11(20), 4704-7, 2009
• Fang WJ, Cui Y, Murray TF, Aldrich JV. Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis. PMID: 19715279 [PubMed - indexed for MEDLINE], Journal of Medicinal Chemistry, 52(18), 5619-25, 2009
• Pereira A, Cao Z, Murray TF, Gerwick WH. Hoiamide a, a sodium channel activator of unusual architecture from a consortium of two papua new Guinea cyanobacteria. PMID: 19716479 [PubMed - indexed for MEDLINE], Chemistry & Biology, 16(8), 893-906, 2009
• George J, Dravid SM, Prakash A, Xie J, Peterson J, Jabba SV, Baden DG, Murray TF. Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons. PMID: 19279266 [PubMed - indexed for MEDLINE], J. Neurosci., 29(10), 3288-301, 2009
• Aldrich JV, Kumar V, Murray TF, Guang W, Wang JB. Dual labeled peptides as tools to study receptors: nanomolar affinity derivatives of TIPP (Tyr-Tic-Phe-Phe) containing an affinity label and biotin as probes of delta opioid receptors. PMID: 19175314 [PubMed - indexed for MEDLINE], Bioconjug Chem., 20(2), 201-4, 2009
• Cao Z, George J, Gerwick WH, Baden DG, Rainier JD, Murray TF. Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons. Epub 2008 Apr 30. PMID: 18448863 [PubMed - indexed for MEDLINE, Journal of Pharmacology and Experimental Therapeutics, 326(2), 604-13, 2008
• Figueiredo MD, Moore JN, Vandenplas ML, Sun WC, Murray TF. Effects of the second-generation synthetic lipid A analogue E5564 on responses to endotoxin in [corrected] equine whole blood and monocytes., American Journal of Veterinary Research, 69(6), 796-803, 2008
• Sun WC, Moore JN, Hurley DJ, Vandenplas ML, Linden J, Cao Z, Murray TF. Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes., Vet Immunol Immunopathol, 121(1-2), 91-100, 2008
• Cao Z, George J, Baden DG, Murray TF. Brevetoxin-induced phosphorylation of Pyk2 and Src in murine neocortical neurons involves distinct signaling pathways., Brain Res, 1184, 17-27, 2007
• LePage KT, Rainier JD, Johnson HW, Baden DG, Murray TF. Gambierol acts as a functional antagonist of neurotoxin site 5 on voltage-gated sodium channels in cerebellar granule neurons., Journal of Pharmacology and Experimental Therapeutics, 323(1), 174-9, 2007
• Sun WC, Moore JN, Hurley DJ, Vandenplas ML, Linden JM, Murray TF. Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils., American Journal of Veterinary Research, 68(9), 981-7, 2007
• Sun, W-C., Moore, J.N., Hurley, D.J., Vadenplas, M.L. and Murray, T.F. Adenosine A2A receptor stimulation inhibits LPS-induced production of ROS by equine neutrophils in a cAMP-dependent, PKA-independent manner., American Journal of Veterinary Research, 68, 649-656, 2007
• Dravid S.M., Erreger K., Yuan H., Nicholson K., Le P., Lyuboslavsky P., Almonte A., Murray E., Mosely C., Barber J., French A., Balster R., Murray T.F., Traynelis S.F. Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block., Journal of Physiology, 581, 107-128, 2007
• Yan X, Benson JM, Gomez AP, Baden DG, Murray TF. Brevetoxin-induced neural insult in the retrosplenial cortex of mouse brain., Inhalation Toxicology, 18, 1109-1116, 2006
• Brandon, C.I., Vandenplas, M., Dookwah, H., Linden, J. and Murray, T.F. Cloning and pharmacological characterization of the equine adenosine A2A receptor: a potential therapeutic target for the treatment of equine., Journal of Veterinary Pharmacology and Therapeutics, 29, 243-253, 2006
• Brandon, C.I., Vandenplas, M., Dookwah, H. and Murray, T.F. Cloning and pharmacological characterization of the equine adenosine A3 receptor., Journal of Veterinary Pharmacology and Therapeutics, 29, 255-263, 2006

Presentations

• S. Mehrotra and T.F. Murray. Regulation of cerebrocortical neuron spontaneous Ca2+ oscillations by metabotropic glutamate receptors. Program/Poster 120.03/A86. 2015 Neuroscience Meeting Planner. Chicago, IL, Society for Neuroscience, 2015. Online, 2015
• Society for Neuroscience 2014 Annual Meeting, Washington DC, "Sodium Channel Activator-stimulated Neurite Outgrowth Involves the Brain-derived Neurotrophic Factor (BDNF) - Tropomyosin related Kinase B (TrkB) Signaling Pathway, 2014
• Molecular Devices Symposium, Nanjing China, "High Throughput Screening and Discovery of Marine Natural Products that Target Neuronal Ion Channels.", 2014
• China Pharmaceutical University, Nanjing China, "Sodium Channel Activator-Induced Enhancement of Cerebrocortical Neuron Neurite Outgrowth Requires both GluN2B NMDA Receptors and p21 Protein (Cdc42/Rac)-activated kinase 1 (PAK1).", 2014
• Cell Biology of the Neuron, Gordon Research Center, Waterville, NH, "Sodium channel activator-induced enhancement of cerebrocortical neuron neurite outgrowth requires both GluN2B NMDA receptors and p21 protein (Cdc42/Rac)-activated kinase 1(PAK1)", 2014
• The Society for Neuroscience 2013 Annual Meeting, San Diego, CA, "Voltage-gated sodium channel activator enhancement of immature cerebrocortical neuron development requires both the N-methyl-D-aspartate receptor 2B (GluN2B) and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1)", 2013
• The Society for Neuroscience 2013 Annual Meeting, San Diego, CA "Quantification of kappa opioid receptor ligand potency and efficacy using the FLIPR Membrane Potential Assay", 2013
• BIT's 3rd Annual World Congress of Marine Biotechnology Hangzhou, China "Discovery and Characterization of Marine Natural Products that Target Neuronal Ion Channels", 2013
• College of Life Sciences, Zhejiang University, Zhijingang Campus, Hangzhou, Zhejiang Province, China "Bidirectional Influence of the Marine Natural Product, Brevetoxin, on NMDA Receptor-Dependent Neuronal Structural Plasticity", 2013
• The Society of Neuroscience 2012 Annual Meeting, New Orleans, LA, "Novel C1-cocaine analogs unlike cocaine or benztropine", 2012
• Experimental Biology, San Diego, CA, 2012
• The Society of Neuroscience 2011 Annual Meeting, Washington, DC, "Kappa-opioid receptor inhibition of calcium oscillations in spinal cord neurons", 2011
• 7th Annual Ion Channel Targets, South San Francisco, CA "Novel Marine Natural Products that Mimic Neuronal Activity-Dependent Neuroplasticity", 2011
• 2011 American Society Pharmacognosy Annual Meeting, San Diego, CA "Regulation of Neuronal Ion Channel Function By Marine Natural Products", 2011
• 2011 Therapeutic Potential of Kappa Opioids in Pain and Addiction, Seattle, WA, "Kappa-opioid receptor inhibition of calcium oscillations in spinal cord neurons", 2011
• University of Iowa, College of Pharmacy, Iowa City, Iowa. "Sodium channel activators that mimic activity-dependent neuronal plasticity:Novel targets for drug discovery.", 2011
• Experimental Biology, San Diego, CA, "Biphasic influence of sodium channel ativation on neuronal structural plasticity" FASEB J 3-17-11 25:1003.3, 2011
• Experimental Biology, San Diego, CA, "Sodium channel activator-induced neurite outgrowth is NMDA receptor dependent and involves a TrkB-PLC{gamma}-Akt pathway" FASEB J 3-17-11 25:1003.3, 2011
• Institute of Biophysics of the Chinese Academy of Sciences, Beijing, China, "Voltage-gated sodium channels regulate neurite outgrowth in developing neurons", 2010
• The Second International Symposium on Membrane Biology, Ning-Bo, China, "Novel sodium channel activators mimic activity-dependent neuronal plasticity", 2010
• Society for Neuroscience, Neuroscience Meeting Planner, San Diego, CA. "Intracelluar sodium regulation of NMDA receptor-dependent neuronal plasticity", 2010
• Society for Neuroscience, Neuroscience Meeting Planner, San Diego, CA. "Kappa opioid receptor regulation of spontaneous calcium oscillations in embryonic spinal cord neurons", 2010
• Screening Europe, Barcelona, Spain, "Voltage-gated sodium channel activators with differing efficacies stimulate neurite outgrowth in cerebrocortical neurons.", 2010
• Target Discovery World Congress, San Francisco, CA, "Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in cerebrocortical neurons.", 2009
• Presentation, "Adenosine as an endogenous anticonvulsant: preclinical characterization and clinical implications" at Merck & Co., 2009
• George, J. and Murray, T.F. Sodium channel activation modulates synchronized calcium oscillations and neuronal morphology in immature cerebrocortical neurons. FASEB Journal 23:946.1, 2009, 2009
• “Neuroscience Research Areas of Emphasis at Creighton University School of Medicine," Jesuit Medical Colleges Symposium, St. Louis University, 2009
• Presentation at University of Mississippi, "Discovery and characterization of neuroactive marine natural products: voltage-gated sodium channels as a common target”, 2009
• Jabba, S., Gerwick, W.H., and Murray, T.F. Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels. Program # 807.2, Society for Neuroscience, 2008
• "Drug Discovery Strategies and High Throughput Screening in an Academic Environment" at Galleon Pharmaceuticals, Horsham, PA, 2008
• Ion Channel Targets, South San Francisco, CA, "Influence of Lipid Soluble Gating Modifier Toxins on Sodium Influx in Neocortical Neurons", 2008
• Seminar entitled “Neuronal responses to sodium channel gating modifiers: From neurotoxicity to dendritogenesis” at the Barrow Neurological Institute, Phoenix, AZ, May 20, 2008., 2008
• George, J., Cao, Z. and Murray, T.F. Brevetoxin sensitizes immature cerebrocortical neurons to NMDA receptor signaling through activation of voltage-gated sodium channels. FASEB Journal 22:721.6, 2008., 2008
• Cao, Z., George, J., Gerwick, W.H. and Murray, T.F. Voltage-dependent sodium channel gating modifier toxins produce sodium influx in neocortical neurons. #1727 The Toxicologist (Society for Toxicology) 2008., 2008
• Seminar entitled “Marine natural products as sodium channel gating modifiers: Neurotoxicants or novel therapeutics?” at Scripps Institution of Oceanography, University of California at San Diego, November 5, 2007., 2007
• Murray, T.F., Xie, J., Peterson, J. and Baden D.G. Brevetoxin activation of voltage-gated sodium channels stimulates neurite outgrowth in immature cerebrocortical neurons. Program No. 34.13. 2007 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007. Online., 2007
• Seminar entitled “Neuronal responses to voltage-gated sodium channel activators: From neurotoxicity to dendritic development” at the Department of Neuroscience, Medical University of South Carolina, Charleston, SC, September 21, 2007., 2007
• Ion Channel Targets, Boston MA, September 10, 2007, “Evaluating Ion Channel Mechanisms in Murine Neuronal Cultures and Human Embryonic Stem Cell-Derived Neurons Using FLIPR and Flex Station.”, 2007
• Xie, J. Peterson, J. Murray, T.F. Brevetoxin enhanced neurite growth involves voltage-gated sodium channel activation with engagement of NMDA receptors and CaM-kinase kinase FASEB JOURNAL 21 (6): A785-A786, 2007, 2007
• Murray, T.F., Yan, X., Gomez, A.P., Baden, D.G., and Benson, J.M. Brevetoxin-induced neural insult in the retrosplenial cortex of mouse brain following inhalation exposure. The Toxicologist 96, 363, 2007., 2007
• LePage, K.T., Rainier, J.D. and Murray, T.F. Gambierol acts as a functional antagonist of neurotoxin site 5 on voltage-gated sodium channels in cerebellar granule cells. The Toxicologist 96, 364, 2007., 2007
• Cao,Z., Baden, D.G. and T.F. Murray. Brevetoxin-induced phosphorylation of Pyk2 and Src in murine neocortical neurons occurs through distinct pathways Program No. 130.12. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online., 2006
• LePage, K.T., Stice, S.L. and T.F.Murray. Activation of voltage-gated sodium channels produces Ca2+ influx in human neural progenitor cell lines derived from embryonic stem cells Program No. 130.14. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience, 2006. Online., 2006

• Jack L. Beal Award, Journal of Natural Products, 2014
• Arthur E. Schwarting Award, Journal of Natural Products, 2010